Cannabegerol is a non-psychoactive cannabinoid found in the hemp and cannabis plant. The acidic form of CBG, CBGa, is the stem cell to all cannabinoids. Cannabinoids such as CBD, THC, and CBC are derived from CBGa. CBG binds to the same receptor as THC, the CB1 receptor, but, unlike THC, CBG does not activate this system resulting in pyscoactivity. As a result of this behavior CBG can be used to reduce the psychoactive effects of THC. CBG has also been shown to have potent antibacterial activity and reduce inflammation. With respect to inflammation, CBG has been shown to help improve gut health and limit the growth of cancers such as colon cancer and glioblastoma. CBG also interacts with the 5HT receptor which is a serotonin receptor. Serotonin is one of the main neurotransmitters in the brain. Many depression and anxiety medications target serotonin production or re-uptake (for example SSRIs).
CBN is a non-psychoactive cannabinoid found in older cannabis plants. CBN is a degradation product of THC but has different effects when compared to THC. CBN can be sedative, anticonvulsant in animal and human studies, and has demonstrated significant properties related to anti-inflammatory and antibiotic. (Appendino et al., 2008; Evans, 2007; McPartland & Russo, 2001; Musty, Karniol, Shirikawa, Takahashi, & Knobel, 1976; Turner, Elsohly, & Boeren, 1980). At Off-grid we aim to use the calming effect of CBN to help make custom products to take advantage of CBN’s useful properties.
Cannabichromene (CBC) is one of the four major classes of cannabinoids, the others being type-CBD, type-CBG and type-THC. CBC is non-psychoactive and has been shown to have anti-inflammatory and antioxidant properties. CBC has been shown to be beneficial for skin health through acne control as well as modulation of sebum. Unlike many of the other cannabinoids, CBC targets a different class of receptors known as the TRP channels. These channels are involved with pain pathways and the immune response. At Off-Grid we are exploiting the antioxidant and anti-inflammatory properties of CBC. The fact that CBC targets these areas through a different mode of action lets us personalize our products depending on what the need is.
CBD is one of the most well known cannabinoids and has been used in a wide variety of consumer and pharmaceutical products. CBD is a non-psychoactive cannabinoid that interacts with the endocannabinoid system (ECS) to help regulate and achieve homeostasis. CBD has been proven to modulate your own body ECS through a variety of mechanisms. Unlike THC which directly targets the human ECS, CBD plays a nuanced role, tipping the scaling in favor of “the calm”. CBD is one of the most studied cannabinoids ever and yet its exact function still remains unclear. At Off-Grid we are part of the community driving the knowledge around this compound. Since CBD does not directly target the ECS reactors it works on the “buddy system.” In combination with other cannabinoids it can modulate their activity.